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LORAZEPAM

Lorazepam is a drug used for treatinganxiety. It is in the benzodiazepine family, the same family that includesdiazepam (Valium), alprazolam (Xanax), clonazepam (Klonopin), flurazepam (Dalmane)and others. Excessive activity of nerves in the brain may cause anxiety and other psychological disorders. Gamma-aminobutyric acid (GABA) is a neurotransmitter in the brain used to send messages . GABA reduces the activity of nerves in the brain. Using Lorazepam and other benzodiazepines may enhance the effects of GABA in the brain. Because lorazepam is extracted from the blood more rapidly than many other benzodiazepines, there is less chance that lorazepam in blood will become too high and become toxic. Lorazepam also has less interactions with other kinds medications than most of the other benzodiazepines. Lorazepam has been approved by the FDA in March 1999.

PREPARATIONS: Tablets: (0.5, 1, and 2 mg). Oral, (2 mg/ml. Injection: 2 mg/ml and 4 mg/ml)

STORAGE: Tablets should be kept at room temperature 15-30°C (59-86°F). Oral solutions should be refrigerated at 2-8°C (36-46°F). Injectable solutions should be refrigerated.

PRESCRIBED FOR: Lorazepam is used for the management of anxiety disorders and the short-term relief of symptoms of anxiety or anxiety associated with different types of depression . Effectiveness of lorazepam and other benzodiazepines has not been adequately studied for treatment after 4 months of use. Lorazepam is effective for insomnia and panic attacks, it is used in with other medications to prevent nausea and vomiting,resulting from chemotherapy. Lorazepam is administered before anesthesia and used for prevention and treatment of alcohol withdrawal.

DOSING: lorazepam is tailored to the patient's needs. The usual dosage for treating anxiety is 2-3 mg/day given in two or three divided doses. Insomnia can be treated with 2-4 mg given when going to bed.

DRUG INTERACTIONS: Lorazepam and all benzodiazepines will interact with other medications and drugs that usually slow the brain's processes such as alcohols, barbiturates, narcotics, and tranquilizers. Some cases of marked sedation occurred when lorazepam was given to patients taking the tranquilizer loxapine or (Loxitane); it is unclear if there is a drug interaction or not, but caution should always be used if lorazepam and loxapine are used at the same time.

PREGNANCY: Lorazepam and other benzodiazepines can be associated with fetal damage and including congenital malformations, when taken by pregnant women in the first trimester of pregnancy. Lorazepam should be avoided if possible in the first trimester and probably throughout pregnancy.

NURSING MOTHERS: It is unknown if lorazepam is secreted in breast milk.

IDE EFFECTS: The most common side effects associated with lorazepam are sedation (15.9% of patients), dizziness, weakness, and sometimes unsteadiness. Side effects include a feeling of depression and loss of orientation, headache, and also sleep disturbance.

 



 

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